Recent research has shed light on the promising role of white button mushroom extract in slowing the progression of prostate cancer. This extract, tested on both mice and human patients, demonstrated a decrease in specific immune-suppressing cells within tumors, indicating its potential as a complementary treatment to existing cancer therapies.
Researchers at City of Hope Comprehensive Cancer Center in California have been investigating the effects of white button mushroom extract on prostate cancer. Their studies revealed a reduction in myeloid-derived suppressor cells, which are known to inhibit the immune system and contribute to cancer progression. In experiments with mice, those treated with the mushroom extract exhibited decreased tumor growth and increased presence of T cells, which are vital in attacking cancer cells.
The study extended to a human clinical trial involving eight prostate cancer patients. Blood samples from these patients showed a similar decrease in myeloid-derived suppressor cells and an increase in cancer-fighting immune cells, such as T cells and natural killer cells, after three months of treatment with the extract. This finding suggests potential benefits of the mushroom extract in enhancing the body’s natural immune response against cancer.
Further research in mice highlighted the synergistic effects of combining white button mushroom extract with immunotherapy, specifically anti-PD-1 antibodies. The combination therapy resulted in greater tumor growth inhibition compared to immunotherapy alone, with treated mice living longer.
The underlying mechanism may involve polysaccharides present in the mushrooms, known as β-glucans, which have been associated with boosting immune response. Identifying the specific β-glucan responsible could enhance cancer treatments. Ongoing studies aim to further understand these mechanisms and their broader applications in oncology.
The findings on white button mushroom extract represent a noteworthy advancement in the pursuit of effective prostate cancer treatments. While results are preliminary, they open avenues for further research into mushroom-based therapies, emphasizing the natural potential in medicine. As research continues, patients are advised to consult healthcare professionals before considering new supplements.
Source: Medicalnewstoday
